Doctor-led aesthetics in Sutton Coldfield
Regenerative skin treatment
Polynucleotides
A regenerative injectable treatment intended to support the skin's natural repair processes, hydration and collagen activity—particularly where skin looks thin, tired or crepey.
Free consultation – a £1 booking fee secures your appointment
What is it?
Skin quality,
not a different face.
Polynucleotides are highly purified DNA fragments used in regenerative aesthetics. Rather than adding facial volume, they are placed within the skin to support repair, hydration and fibroblast activity.
They can be considered for the face, neck, décolletage or delicate eye area. Product choice and depth depend on the treatment area and your individual skin assessment.
Potential benefits
Subtle improvements.
Thoughtfully planned.
Benefits vary between individuals and develop according to the product, treatment area and your skin's response.
Improved hydration and elasticity
Smoother fine or crepey texture
A healthier, more rested appearance
In more detail
Polynucleotides, explained.
Polynucleotides are chosen for skin quality rather than facial reshaping. The product, concentration, treatment area and course are selected after assessing your skin, anatomy and main concern.
The under-eye area
Polynucleotides may be considered where the skin looks thin, finely lined, crepey or tired. They do not replace lost volume like a traditional filler, and they will not correct every cause of dark circles, hollowness or puffiness. Careful assessment is essential.
Face and cheeks
Treatment can be used to support overall skin texture, hydration and elasticity across the face. The aim is gradual skin-quality improvement rather than adding contour or changing facial proportions.
Neck and décolletage
Some formulations may be used on the neck or décolletage where skin appears crepey or sun-affected. Product choice and technique depend on skin thickness, medical history and the area being treated.
How treatment is delivered
Small amounts are placed within the skin using a fine needle, with the pattern and depth adapted to the treatment area. A topical anaesthetic or other comfort measures may be discussed when appropriate.
A course, not an instant fix
A course of three sessions, usually spaced two to four weeks apart, is commonly planned at Dr Maryam Aesthetics. Changes tend to appear gradually over the following weeks. Maintenance is considered individually after review.
Aftercare and downtime
Temporary bumps, redness, tenderness, swelling and bruising are expected possibilities. Swelling can be more noticeable around the eyes. You receive individual aftercare instructions and guidance on when to contact the clinic.
Choosing a treatment
Polynucleotides or Profhilo?
Neither treatment is automatically better. They have different formulations and are selected according to your skin, treatment area and priorities. In some cases they may be used at different stages of a wider plan.
QuestionPolynucleotidesProfhilo®
Main focus
Regenerative support for skin texture, elasticity and delicate areas.
Broad hydration and skin-quality support using stabilised hyaluronic acid.
Adds facial volume?
Not intended to sculpt or replace volume like a traditional dermal filler.
Not a traditional volumising filler and is not used to contour features.
Typical areas
Under-eye area, face, neck or décolletage, depending on the formulation.
Most commonly planned across the face or neck using designated treatment points.
Typical initial course
Often three sessions, usually two to four weeks apart.
Usually two sessions around four weeks apart.
How to choose
Often considered when repair, fine texture or the delicate eye area is the priority.
Often considered when widespread dehydration or loss of skin firmness is the priority.
Who is suitable?
A medical decision,
made together.
May be suitable if you want to…
✓ Improve thin, tired or crepey-looking skin
✓ Support the delicate under-eye area
✓ Address texture on the face, neck or décolletage
✓ Choose regeneration rather than volume
Treatment may need to be avoided or postponed if…
— You are pregnant or breastfeeding
— You have active infection or inflammation in the treatment area
— You have a relevant allergy, autoimmune condition or uncontrolled illness
— Blood-thinning medication or medical history requires review
Your treatment journey
ConsultationMedical and skin assessment
Initial courseThree sessions
SpacingUsually 2–4 weeks apart
Follow-upReview and maintenance plan
Recovery & downtime
What to expect.
Small bumps, redness, tenderness and swelling are common immediately after treatment. Bruising is possible, especially around the eyes. Most visible effects settle over 24–72 hours, although bruising can last longer.
A full aftercare plan is provided at your appointment. Contact the clinic promptly if you have unexpected or concerning symptoms.
Evidence & expectations
Promising research, individual outcomes.
Published reviews and clinical studies report encouraging findings for skin hydration, elasticity, texture and fine lines. Research has also examined the delicate periorbital area, where gradual improvements in skin appearance and patient-reported satisfaction have been observed.
The evidence base is still developing and products, protocols and study designs vary. Research findings cannot predict an individual result. A consultation is needed to decide whether the treatment is appropriate and what a realistic outcome may be for you.
Further reading: 2024 review of polynucleotides in aesthetic medicine ↗ · Randomised periocular comparison study ↗ · 2026 observational periorbital study ↗
Recommended course
Polynucleotide Regeneration
- ✓ Three polynucleotide sessions
- ✓ Clinical review
Frequently asked
Your questions,
answered.
Are polynucleotides a filler?+
No. They are not used to sculpt or replace volume. The aim is to support skin quality and regeneration.
How many sessions are recommended?+
A course of three treatments is commonly advised, usually spaced two to four weeks apart. Your plan may vary.
Can the under-eye area be treated?+
It may be suitable for some people. The skin, anatomy and cause of the concern must be assessed first; not every under-eye concern is appropriate for injectable treatment.
Can I combine polynucleotides with Profhilo?+
A staged combination may be considered where both hydration and regenerative support are helpful. Timing is planned individually after consultation.
Are polynucleotides made from fish DNA?+
Many injectable polynucleotide products use highly purified DNA fragments derived from salmon or trout. The exact source depends on the product. Tell Dr Maryam about any fish allergy or previous reaction so the specific product information can be checked before treatment.
Can polynucleotides improve dark circles?+
They may help when thin, crepey skin contributes to a tired under-eye appearance. Dark circles can also be caused by pigment, visible vessels, hollowness, shadowing or swelling, and these causes may need a different approach.
When might I notice a change?+
Changes are gradual rather than immediate. Some people notice hydration or texture first, with further skin-quality changes developing during and after the treatment course. Results and timing vary.
How long do the effects last?+
Duration varies with the product, treatment area, skin quality, lifestyle and response to the initial course. Maintenance is discussed at review rather than promised in advance.
Is the treatment painful?+
You may feel brief stinging, pressure or small pinches at the injection points. Comfort measures can be discussed, particularly for the delicate eye area.
What if I swell or bruise?+
Mild swelling and bruising can occur and may be more noticeable around the eyes. Follow your aftercare advice and contact the clinic promptly if symptoms are severe, worsening or unexpected.
Your consultation
Ready to begin?
Free consultation – a £1 booking fee secures your appointment